Targeting the CBM complex causes Treg cells to prime tumors for immune checkpoint therapy

Solid tumors are infiltrated by effector T cells (Teff) with the potential to control or reject them, as well as by regulatory T cells (Treg) that restrict the function of Teff and thereby promote tumor growth.(1) The anti-tumor activity of Teff can be therapeutically unleashed and is now being expl...

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Detalles Bibliográficos
Autores principales: Pilato, Mauro Di, Kim, Edward Y., Cadilha, Bruno L., Pruessmann, Jasper N., Nasrallah, Mazen N., Seruggia, Davide, Usmani, Shariq M., Misale, Sandra, Zappulli, Valentina, Carrizosa, Esteban, Mani, Vinidhra, Ligorio, Matteo, Warner, Ross D., Medoff, Benjamin D., Marangoni, Francesco, Villani, Alexandra-Chloe, Mempel, Thorsten R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656391/
https://www.ncbi.nlm.nih.gov/pubmed/31092922
http://dx.doi.org/10.1038/s41586-019-1215-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656391/
https://www.ncbi.nlm.nih.gov/pubmed/31092922
http://dx.doi.org/10.1038/s41586-019-1215-2

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