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Rescue of Rod Synapses by Induction of Ca(v) Alpha 1F in the Mature Ca(v)1.4 Knock-Out Mouse Retina

PURPOSE: Ca(v)1.4 is a voltage-gated calcium channel clustered at the presynaptic active zones of photoreceptors. Ca(v)1.4 functions in communication by mediating the Ca(2+) influx that triggers neurotransmitter release. It also aids in development since rod ribbon synapses do not form in Ca(v)1.4 k...

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Detalles Bibliográficos
Autores principales: Laird, Joseph G., Gardner, Sarah H., Kopel, Ariel J., Kerov, Vasily, Lee, Amy, Baker, Sheila A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656410/
https://www.ncbi.nlm.nih.gov/pubmed/31335952
http://dx.doi.org/10.1167/iovs.19-27226