The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease

INTRODUCTION: Clinical trials on preclinical Alzheimer’s disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more efficiently than models of time to progression. METHO...

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Detalles Bibliográficos
Autores principales: Li, Dan, Iddi, Samuel, Aisen, Paul S., Thompson, Wesley K., Donohue, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656701/
https://www.ncbi.nlm.nih.gov/pubmed/31367671
http://dx.doi.org/10.1016/j.trci.2019.04.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656701/
https://www.ncbi.nlm.nih.gov/pubmed/31367671
http://dx.doi.org/10.1016/j.trci.2019.04.004

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