E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration

In prior work we demonstrated that loss of E2F transcription factors inhibits metastasis. Here we address the mechanisms for this phenotype and identify the E2F regulated genes that coordinate tumor cell metastasis. Transcriptomic profiling of E2F1 knockout tumors identified a role for E2F1 as a mas...

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Detalles Bibliográficos
Autores principales: Hollern, Daniel P., Swiatnicki, Matthew R., Rennhack, Jonathan P., Misek, Sean A., Matson, Brooke C., McAuliff, Andrew, Gallo, Kathleen A., Caron, Kathleen M., Andrechek, Eran R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656723/
https://www.ncbi.nlm.nih.gov/pubmed/31341204
http://dx.doi.org/10.1038/s41598-019-47218-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656723/
https://www.ncbi.nlm.nih.gov/pubmed/31341204
http://dx.doi.org/10.1038/s41598-019-47218-0

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