Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems

Physiologically based pharmacokinetic (PBPK) models are an important type of systems model used commonly in drug development before commencement of first-in-human studies. Due to structural complexity, these models are not easily utilised for future data-driven population pharmacokinetic (PK) analys...

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Detalles Bibliográficos
Autores principales: Pan, Shan, Duffull, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656793/
https://www.ncbi.nlm.nih.gov/pubmed/31227954
http://dx.doi.org/10.1007/s10928-019-09644-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656793/
https://www.ncbi.nlm.nih.gov/pubmed/31227954
http://dx.doi.org/10.1007/s10928-019-09644-5

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