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Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems
Physiologically based pharmacokinetic (PBPK) models are an important type of systems model used commonly in drug development before commencement of first-in-human studies. Due to structural complexity, these models are not easily utilised for future data-driven population pharmacokinetic (PK) analys...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656793/ https://www.ncbi.nlm.nih.gov/pubmed/31227954 http://dx.doi.org/10.1007/s10928-019-09644-5 |