Administration of Tramadol or Buprenorphine via the drinking water for post-operative analgesia in a mouse-osteotomy model

Adequate analgesia is essential whenever pain might occur in animal experiments. Unfortunately, the selection of suitable analgesics for mice in bone-linked models is limited. Here, we evaluated two analgesics – Tramadol [0.1 mg/ml (T(low)) vs. 1 mg/ml (T(high))] and Buprenorphine (Bup; 0.009 mg/ml)...

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Detalles Bibliográficos
Autores principales: Jirkof, Paulin, Durst, Mattea, Klopfleisch, Robert, Palme, Rupert, Thöne-Reineke, Christa, Buttgereit, Frank, Schmidt-Bleek, Katharina, Lang, Annemarie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656891/
https://www.ncbi.nlm.nih.gov/pubmed/31341225
http://dx.doi.org/10.1038/s41598-019-47186-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656891/
https://www.ncbi.nlm.nih.gov/pubmed/31341225
http://dx.doi.org/10.1038/s41598-019-47186-5

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