Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants

Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adult fluconazole physiologically‐based pharmacokinetic (PBPK) model was scaled to infants, accounting for age dependencies in glomerular...

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Detalles Bibliográficos
Autores principales: Gerhart, Jacqueline G., Watt, Kevin M., Edginton, Andrea, Wade, Kelly C., Salerno, Sara N., Benjamin, Daniel K., Smith, P. Brian, Hornik, Christoph P., Cohen‐Wolkowiez, Michael, Duara, Shahnaz, Ross, Ashley, Shattuck, Karen, Stewart, Dan L., Neu, Natalie, Gonzalez, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656941/
https://www.ncbi.nlm.nih.gov/pubmed/31087536
http://dx.doi.org/10.1002/psp4.12414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656941/
https://www.ncbi.nlm.nih.gov/pubmed/31087536
http://dx.doi.org/10.1002/psp4.12414

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