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Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF

BACKGROUND: Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs during adhesion process remains unknown. It has been hypothesized that CAFs contribu...

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Detalles Bibliográficos
Autores principales: Zhang, Rongsheng, Qi, Fan, Shao, Shengli, Li, Geng, Feng, Yongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657169/
https://www.ncbi.nlm.nih.gov/pubmed/31367190
http://dx.doi.org/10.1186/s12935-019-0914-y