Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

Cytochrome P450s CYP1A1 and CYP1A2 can metabolize a broad range of foreign compounds and drugs. However, these enzymes have significantly overlapping substrate specificities. To establish their relative contribution to drug metabolism in vivo, we used a combination of mice humanized for CYP1A1 and C...

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Detalles Bibliográficos
Autores principales: Kapelyukh, Y., Henderson, C. J., Scheer, N., Rode, A., Wolf, C. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657216/
https://www.ncbi.nlm.nih.gov/pubmed/31147315
http://dx.doi.org/10.1124/dmd.119.087718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657216/
https://www.ncbi.nlm.nih.gov/pubmed/31147315
http://dx.doi.org/10.1124/dmd.119.087718

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