Clinical Implications and Translation of an Off-Target Pharmacology Profiling Hit: Adenosine Uptake Inhibition In Vitro

Off-target activities of drug candidates observed during in vitro pharmacological profiling frequently do not translate to adverse events (AEs) in human. This could be because off-target activities do not have functional consequences, are not observed at exposures achieved during clinical testing, o...

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Detalles Bibliográficos
Autores principales: Amouzadeh, Hamid R., Dimery, Isaiah, Werner, Jonathan, Ngarmchamnanrith, Gataree, Engwall, Michael J, Vargas, Hugo M., Arrindell, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657233/
https://www.ncbi.nlm.nih.gov/pubmed/31330495
http://dx.doi.org/10.1016/j.tranon.2019.05.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657233/
https://www.ncbi.nlm.nih.gov/pubmed/31330495
http://dx.doi.org/10.1016/j.tranon.2019.05.018

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