Optimized administration of hetIL-15 expands lymphocytes and minimizes toxicity in rhesus macaques

The common γ-chain cytokine interleukin-15 (IL-15) plays a significant role in regulating innate and adaptive lymphocyte homeostasis and can stimulate anti-tumor activity of leukocytes. We have previously shown that the circulating IL-15 in the plasma is the heterodimeric form (hetIL-15), produced u...

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Detalles Bibliográficos
Autores principales: Bergamaschi, Cristina, Watson, Dionysios C., Valentin, Antonio, Bear, Jenifer, Peer, Cody J., Figg, William D., Felber, Barbara K., Pavlakis, George N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657354/
https://www.ncbi.nlm.nih.gov/pubmed/29402721
http://dx.doi.org/10.1016/j.cyto.2018.01.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657354/
https://www.ncbi.nlm.nih.gov/pubmed/29402721
http://dx.doi.org/10.1016/j.cyto.2018.01.011

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