Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming

Gata4, Hand2, Mef2c, and Tbx5 (GHMT) can reprogram transduced fibroblasts into induced pacemaker-like myocytes (iPMs), but the underlying mechanisms remain obscure. Here, we explore the role of Hand2 in iPM formation by using a combination of transcriptome, genome, and biochemical as-says. We found...

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Detalles Bibliográficos
Autores principales: Fernandez-Perez, Antonio, Sathe, Adwait Amod, Bhakta, Minoti, Leggett, Kayla, Xing, Chao, Munshi, Nikhil Vilas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657359/
https://www.ncbi.nlm.nih.gov/pubmed/31116981
http://dx.doi.org/10.1016/j.celrep.2019.04.077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657359/
https://www.ncbi.nlm.nih.gov/pubmed/31116981
http://dx.doi.org/10.1016/j.celrep.2019.04.077

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