Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization

Mutations and variations in the leucine-rich repeat kinase 2 (LRRK2) gene are strongly associated with an increased risk to develop Parkinson’s disease (PD). Most pathogenic LRRK2 mutations display increased kinase activity, which is believed to underlie LRRK2-mediated toxicity. Therefore, major eff...

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Detalles Bibliográficos
Autores principales: De Wit, T., Baekelandt, V., Lobbestael, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657425/
https://www.ncbi.nlm.nih.gov/pubmed/30592011
http://dx.doi.org/10.1007/s12035-018-1449-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657425/
https://www.ncbi.nlm.nih.gov/pubmed/30592011
http://dx.doi.org/10.1007/s12035-018-1449-2

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