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Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization
Mutations and variations in the leucine-rich repeat kinase 2 (LRRK2) gene are strongly associated with an increased risk to develop Parkinson’s disease (PD). Most pathogenic LRRK2 mutations display increased kinase activity, which is believed to underlie LRRK2-mediated toxicity. Therefore, major eff...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657425/ https://www.ncbi.nlm.nih.gov/pubmed/30592011 http://dx.doi.org/10.1007/s12035-018-1449-2 |