Regulation of TSHR Expression in the Thyroid and Thymus May Contribute to TSHR Tolerance Failure in Graves' Disease Patients via Two Distinct Mechanisms

Graves' disease (GD) involves the presence of agonistic auto-antibodies against the thyrotropin receptor (TSHR), which are responsible for the clinical symptoms. While failure of TSHR tolerance is central to GD pathogenesis, the process leading to this failure remains poorly understood. Two mec...

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Detalles Bibliográficos
Autores principales: Marín-Sánchez, Ana, Álvarez-Sierra, Daniel, González, Oscar, Lucas-Martin, Ana, Sellés-Sánchez, Alicia, Rudilla, Francesc, Enrich, Emma, Colobran, Roger, Pujol-Borrell, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657650/
https://www.ncbi.nlm.nih.gov/pubmed/31379878
http://dx.doi.org/10.3389/fimmu.2019.01695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657650/
https://www.ncbi.nlm.nih.gov/pubmed/31379878
http://dx.doi.org/10.3389/fimmu.2019.01695

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