Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes

The structure of ligand-binding sites has been shown to profoundly influence the evolution of function in homomeric protein complexes. Complexes with multichain binding sites (MBSs) have more conserved quaternary structure, more similar binding sites and ligands between homologs, and evolve new func...

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Detalles Bibliográficos
Autores principales: Abrusán, György, Marsh, Joseph A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657754/
https://www.ncbi.nlm.nih.gov/pubmed/31004156
http://dx.doi.org/10.1093/molbev/msz093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657754/
https://www.ncbi.nlm.nih.gov/pubmed/31004156
http://dx.doi.org/10.1093/molbev/msz093

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