Immunization expands HIV-1 V3-glycan specific B-cells in mice and macaques

Broadly neutralizing monoclonal antibodies protect against HIV-1 infection in animal models, suggesting that a vaccine that elicits them in humans would be effective. However, it has not yet been possible to elicit adequate serologic responses by vaccination. To activate B-cells expressing precursor...

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Detalles Bibliográficos
Autores principales: Escolano, Amelia, Gristick, Harry B., Abernathy, Morgan E., Merkenschlager, Julia, Gautam, Rajeev, Oliveira, Thiago Y., Pai, Joy, West, Anthony P., Barnes, Christopher O., Cohen, Alexander A., Wang, Haoqing, Golijanin, Jovana, Yost, Daniel, Keeffe, Jennifer R., Wang, Zijun, Zhao, Peng, Yao, Kai-Hui, Bauer, Jens, Nogueira, Lilian, Gao, Han, Voll, Alisa V., Montefiori, David C., Seaman, Michael S., Gazumyan, Anna, Silva, Murillo, McGuire, Andrew T., Stamatatos, Leonidas, Irvine, Darrell J., Wells, Lance, Martin, Malcolm A., Bjorkman, Pamela J., Nussenzweig, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657810/
https://www.ncbi.nlm.nih.gov/pubmed/31142836
http://dx.doi.org/10.1038/s41586-019-1250-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657810/
https://www.ncbi.nlm.nih.gov/pubmed/31142836
http://dx.doi.org/10.1038/s41586-019-1250-z

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