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GRP78 translocation to the cell surface and O-GlcNAcylation of VE-Cadherin contribute to ER stress-mediated endothelial permeability

Increased O-GlcNAcylation, a well-known post-translational modification of proteins causally linked to various detrimental cellular functions in pathological conditions including diabetic retinopathy (DR). Previously we have shown that endothelial activation induced by inflammation and hyperglycemia...

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Detalles Bibliográficos
Autores principales: Lenin, Raji, Nagy, Peter G., Jha, Kumar Abhiram, Gangaraju, Rajashekhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658495/
https://www.ncbi.nlm.nih.gov/pubmed/31346222
http://dx.doi.org/10.1038/s41598-019-47246-w