IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation

Activation of macrophage proinflammatory and antimicrobial phenotypes is regulated by IFN-γ and LPS via synergistic induction of canonical, inflammatory NF-κB target genes. However, whether IFN-γ negatively regulates components of the LPS response, and how this may affect macrophage activation, is s...

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Detalles Bibliográficos
Autores principales: Kang, Kyuho, Bachu, Mahesh, Park, Sung Ho, Kang, Keunsoo, Bae, Seyeon, Park-Min, Kyung-Hyun, Ivashkiv, Lionel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658531/
https://www.ncbi.nlm.nih.gov/pubmed/31346169
http://dx.doi.org/10.1038/s41467-019-11147-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658531/
https://www.ncbi.nlm.nih.gov/pubmed/31346169
http://dx.doi.org/10.1038/s41467-019-11147-3

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