Cargando…

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation

Activation of macrophage proinflammatory and antimicrobial phenotypes is regulated by IFN-γ and LPS via synergistic induction of canonical, inflammatory NF-κB target genes. However, whether IFN-γ negatively regulates components of the LPS response, and how this may affect macrophage activation, is s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Kyuho, Bachu, Mahesh, Park, Sung Ho, Kang, Keunsoo, Bae, Seyeon, Park-Min, Kyung-Hyun, Ivashkiv, Lionel B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658531/ https://www.ncbi.nlm.nih.gov/pubmed/31346169 http://dx.doi.org/10.1038/s41467-019-11147-3

Ejemplares similares

Type I IFNs and TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation
por: Park, Sung Ho, et al.
Publicado: (2017)

Induction of IFN-αβ enables Listeria monocytogenes to suppress macrophage activation by IFN-γ
por: Rayamajhi, Manira, et al.
Publicado: (2010)

CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes
por: Yang, Chao, et al.
Publicado: (2022)

MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS
por: Fujii, Takayuki, et al.
Publicado: (2021)

SEPTIN2 suppresses an IFN-γ-independent, proinflammatory macrophage activation pathway
por: Fu, Beibei, et al.
Publicado: (2023)

Activation of OSM-STAT3 Epigenetically Regulates Tumor-Promoting Transcriptional Programs in Cervical Cancer
por: Noh, Junho, et al.
Publicado: (2022)

Twist mediates suppression of inflammation by type I IFNs and Axl
por: Sharif, M. Nusrat, et al.
Publicado: (2006)

Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4
por: Colombo, Giorgia, et al.
Publicado: (2022)

The antihypertension drug doxazosin suppresses JAK/STATs phosphorylation and enhances the effects of IFN-α/γ-induced apoptosis
por: Park, Mi Sun, et al.
Publicado: (2014)

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation
por: Su, Xiaodi, et al.
Publicado: (2015)

IFN-γ is essential for alveolar macrophage–driven pulmonary inflammation in macrophage activation syndrome
por: Gao, Denny K., et al.
Publicado: (2021)

TLR2-Dependent Inhibition of Macrophage Responses to IFN-γ Is Mediated by Distinct, Gene-Specific Mechanisms
por: Benson, Sarah A., et al.
Publicado: (2009)

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes
por: Foldi, Julia, et al.
Publicado: (2016)

ILC1-derived IFN-γ regulates macrophage activation in colon cancer
por: Zhang, Yandong, et al.
Publicado: (2023)

Exosomes Released from M.tuberculosis Infected Cells Can Suppress IFN-γ Mediated Activation of Naïve Macrophages
por: Singh, Prachi P., et al.
Publicado: (2011)

Progesterone Alters Kynurenine Pathway Activation in IFN-γ-Activated Macrophages – Relevance for Neuroinflammatory Diseases
por: de Bie, J., et al.
Publicado: (2016)

High levels of interferon-gamma (IFNγ) in macrophage activation syndrome (MAS) and CXCL9 levels as a biomarker for IFNγ production in MAS
por: Bracaglia, C, et al.
Publicado: (2015)

Macrophage activation by IFN-γ triggers restriction of phagosomal copper from intracellular pathogens
por: Shen, Qian, et al.
Publicado: (2018)

Correction: ILC1-derived IFN-γ regulates macrophage activation in colon cancer
por: Zhang, Yandong, et al.
Publicado: (2023)

Combined Detection of IFN-γ and Lymphocyte Subsets with Activation Indicators in the Clinical Application of Mycobacterium Tuberculosis Infection at Different Times
por: Chen, Yiwen, et al.
Publicado: (2023)

Purpurin suppresses atopic dermatitis via TNF-α/IFN-γ-induced inflammation in HaCaT cells
por: Oh, Jae-Hoon, et al.
Publicado: (2022)

STAT1 deficiency redirects IFN signalling toward suppression of TLR response through a feedback activation of STAT3
por: Kim, Hun Sik, et al.
Publicado: (2015)

IFNγ: Issuing macrophages a license to kill
por: Bashyam, Hema
Publicado: (2007)

Response of human periodontal ligament stem cells to IFN-γ and TLR-agonists
por: Andrukhov, Oleh, et al.
Publicado: (2017)

IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella
por: Lin, Qiubin, et al.
Publicado: (2021)

ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes
por: Schroeder, Linda, et al.
Publicado: (2017)

Differential gene expression in LPS/IFNγ activated microglia and macrophages: in vitro versus in vivo
por: Schmid, Christoph D, et al.
Publicado: (2009)

The synergistic interaction between the calcineurin B subunit and IFN-γ enhances macrophage antitumor activity
por: Su, Z, et al.
Publicado: (2015)

IFN-γ fails to overcome inhibition of selected macrophage activation events in response to pathogenic mycobacteria
por: Thirunavukkarasu, Shyamala, et al.
Publicado: (2017)

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling
por: Apriamashvili, Georgi, et al.
Publicado: (2022)

The Different Effects of IFN-β and IFN-γ on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells
por: Du, Jingchun, et al.
Publicado: (2019)

Identification of the Molecular Mechanism by which TLR Ligation and IFN-γ Synergize to Induce Mig
por: Powell, Jonathan D., et al.
Publicado: (2004)

TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
por: Spiller, Stephan, et al.
Publicado: (2008)

TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
por: Spiller, Stephan, et al.
Publicado: (2008)

Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages
por: Huynh, Linda, et al.
Publicado: (2016)

Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages
por: Neehus, Anna-Lena, et al.
Publicado: (2017)

Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
por: Moreira-Teixeira, Lúcia, et al.
Publicado: (2016)

Epigenetic Activation and Silencing of the Gene that Encodes IFN-γ
por: Aune, Thomas M., et al.
Publicado: (2013)

NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling
por: López-López, Susana, et al.
Publicado: (2021)

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
por: Sokhi, Upneet K., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_90sl7om1dmukoqq6qov9hf0870