Differential binding affinity of tau repeat region R2 with neuronal-specific β-tubulin isotypes

Tau is a microtubule-associated protein whose C-terminal domain consisting of four repeat regions R1, R2, R3 and R4 binds to microtubules to stabilize them. In several neurodegenerative diseases, tau detaches from microtubules to form insoluble aggregates leading to tauopathy. Microtubules are made...

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Detalles Bibliográficos
Autores principales: Bhandare, Vishwambhar Vishnu, Kumbhar, Bajarang Vasant, Kunwar, Ambarish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658543/
https://www.ncbi.nlm.nih.gov/pubmed/31346240
http://dx.doi.org/10.1038/s41598-019-47249-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658543/
https://www.ncbi.nlm.nih.gov/pubmed/31346240
http://dx.doi.org/10.1038/s41598-019-47249-7

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