Cu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of H(2)O(2) via cysteine-dependent redox short-circuit

The Cu/Zn−superoxide dismutase (SOD1) is a ubiquitous enzyme that catalyzes the dismutation of superoxide radicals to oxygen and hydrogen peroxide. In addition to this principal reaction, the enzyme is known to catalyze, with various efficiencies, several redox side-reactions using alternative subst...

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Detalles Bibliográficos
Autores principales: Bakavayev, Shamchal, Chetrit, Nimrod, Zvagelsky, Tatiana, Mansour, Rasha, Vyazmensky, Maria, Barak, Zeev, Israelson, Adrian, Engel, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658568/
https://www.ncbi.nlm.nih.gov/pubmed/31346243
http://dx.doi.org/10.1038/s41598-019-47326-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658568/
https://www.ncbi.nlm.nih.gov/pubmed/31346243
http://dx.doi.org/10.1038/s41598-019-47326-x

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