MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation via Coregulating BACE1 and PRKACB

Alzheimer’s disease (AD) is characterized by two landmark pathologies, the overproduction of amyloid-beta peptides (Aβ), predominated by the β-amyloid protein precursor cleaving enzyme 1 (BACE1), and hyperphosphorylation of the microtubule protein, tau, because of an imbalance in a kinase/phosphatas...

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Detalles Bibliográficos
Autores principales: Wang, Linlin, Liu, Jianghong, Wang, Qian, Jiang, Hailun, Zeng, Li, Li, Zhuorong, Liu, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658613/
https://www.ncbi.nlm.nih.gov/pubmed/31379578
http://dx.doi.org/10.3389/fphar.2019.00806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658613/
https://www.ncbi.nlm.nih.gov/pubmed/31379578
http://dx.doi.org/10.3389/fphar.2019.00806

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