Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors

The attachment of myristate to the N-terminal glycine of certain proteins is largely a co-translational modification catalyzed by N-myristoyltransferase (NMT), and involved in protein membrane-localization. Pathogen NMT is a validated therapeutic target in numerous infectious diseases including mala...

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Detalles Bibliográficos
Autores principales: Schlott, Anja C., Mayclin, Stephen, Reers, Alexandra R., Coburn-Flynn, Olivia, Bell, Andrew S., Green, Judith, Knuepfer, Ellen, Charter, David, Bonnert, Roger, Campo, Brice, Burrows, Jeremy, Lyons-Abbott, Sally, Staker, Bart L., Chung, Chun-Wa, Myler, Peter J., Fidock, David A., Tate, Edward W., Holder, Anthony A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658617/
https://www.ncbi.nlm.nih.gov/pubmed/31080074
http://dx.doi.org/10.1016/j.chembiol.2019.03.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658617/
https://www.ncbi.nlm.nih.gov/pubmed/31080074
http://dx.doi.org/10.1016/j.chembiol.2019.03.015

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