Cargando…

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors

The attachment of myristate to the N-terminal glycine of certain proteins is largely a co-translational modification catalyzed by N-myristoyltransferase (NMT), and involved in protein membrane-localization. Pathogen NMT is a validated therapeutic target in numerous infectious diseases including mala...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schlott, Anja C., Mayclin, Stephen, Reers, Alexandra R., Coburn-Flynn, Olivia, Bell, Andrew S., Green, Judith, Knuepfer, Ellen, Charter, David, Bonnert, Roger, Campo, Brice, Burrows, Jeremy, Lyons-Abbott, Sally, Staker, Bart L., Chung, Chun-Wa, Myler, Peter J., Fidock, David A., Tate, Edward W., Holder, Anthony A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658617/ https://www.ncbi.nlm.nih.gov/pubmed/31080074 http://dx.doi.org/10.1016/j.chembiol.2019.03.015

Ejemplares similares

Identification of and Structural Insights into Hit Compounds Targeting N-Myristoyltransferase for Cryptosporidium Drug Development
por: Fenwick, Michael K., et al.
Publicado: (2023)

QSAR Study of N-Myristoyltransferase Inhibitors of Antimalarial Agents
por: Santos-Garcia, Letícia, et al.
Publicado: (2018)

Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts
por: Rodríguez-Hernández, Diego, et al.
Publicado: (2023)

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase
por: Yu, Zhiyong, et al.
Publicado: (2015)

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase
por: Rackham, Mark D., et al.
Publicado: (2012)

Antimalarial drug discovery: progress and approaches
por: Siqueira-Neto, Jair L, et al.
Publicado: (2023)

Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases
por: Kallemeijn, Wouter W., et al.
Publicado: (2019)

Antimalarial drug discovery – the path towards eradication
por: BURROWS, JEREMY N, et al.
Publicado: (2014)

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase
por: Goncalves, Victor, et al.
Publicado: (2016)

N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells
por: Thinon, Emmanuelle, et al.
Publicado: (2016)

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs
por: Bell, Andrew S., et al.
Publicado: (2012)

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase
por: Rackham, Mark D., et al.
Publicado: (2015)

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites
por: Olaleye, Tayo O., et al.
Publicado: (2014)

Whole Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A
por: Goya Grocin, Andrea, et al.
Publicado: (2019)

Structure-Based Design of Potent and Selective LeishmaniaN-Myristoyltransferase Inhibitors
por: Hutton, Jennie A., et al.
Publicado: (2014)

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)
por: Rackham, Mark D., et al.
Publicado: (2014)

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors
por: Brannigan, James A., et al.
Publicado: (2014)

Crystal structure of a putative short-chain dehydrogenase/reductase from Paraburkholderia xenovorans
por: Davidson, Jaysón, et al.
Publicado: (2022)

The role of N-myristoyltransferase 1 in tumour development
por: Wang, Hong, et al.
Publicado: (2023)

N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus
por: Fang, Wenxia, et al.
Publicado: (2015)

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes
por: Bell, Andrew S., et al.
Publicado: (2020)

Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase
por: Robinson, David A., et al.
Publicado: (2015)

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors
por: Bayliss, Tracy, et al.
Publicado: (2017)

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase
por: Roberts, Adam J., et al.
Publicado: (2014)

Prioritization of Molecular Targets for Antimalarial Drug Discovery
por: Forte, Barbara, et al.
Publicado: (2021)

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness
por: Frearson, Julie A., et al.
Publicado: (2010)

Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism
por: Fedoryshchak, Roman O., et al.
Publicado: (2020)

Accelerated evolution and spread of multidrug-resistant Plasmodium falciparum takes down the latest first-line antimalarial drug in southeast Asia
por: Ménard, Didier, et al.
Publicado: (2019)

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani
por: Corpas-Lopez, Victoriano, et al.
Publicado: (2018)

Inhibition of N‐myristoyltransferase1 affects dengue virus replication
por: Suwanmanee, San, et al.
Publicado: (2019)

Inhibitor Trapping in N-Myristoyltransferases as a Mechanism for Drug Potency
por: Spassov, Danislav S., et al.
Publicado: (2023)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
por: Brand, Stephen, et al.
Publicado: (2011)

N-myristoyltransferase: A potential novel diagnostic marker for colon cancer
por: Shrivastav, Anuraag, et al.
Publicado: (2007)

Novel Hits for N-Myristoyltransferase Inhibition Discovered by Docking-Based Screening
por: Spassov, Danislav S., et al.
Publicado: (2022)

Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani
por: Wright, Megan H., et al.
Publicado: (2015)

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis
por: Brannigan, James A., et al.
Publicado: (2010)

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus
por: Mousnier, Aurélie, et al.
Publicado: (2018)

Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone
por: Skinner-Adams, Tina S., et al.
Publicado: (2019)

Crystal structure of a short-chain dehydrogenase/reductase from Burkholderia phymatum in complex with NAD
por: Alenazi, Jawaher, et al.
Publicado: (2022)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
por: Antonova-Koch, Yevgeniya, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1lmj6cpot38c4f18est1s9bvj7