Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ

NOTCH plays a pivotal role during normal development and in congenital disorders and cancer. γ-secretase inhibitors are commonly used to probe NOTCH function, but also block processing of numerous other proteins. We discovered a new class of small molecule inhibitor that disrupts the interaction bet...

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Detalles Bibliográficos
Autores principales: Hurtado, Cecilia, Safarova, Alena, Smith, Michael, Chung, Raeeun, Bruyneel, Arne A. N., Gomez-Galeno, Jorge, Oswald, Franz, Larson, Christopher J., Cashman, John R., Ruiz-Lozano, Pilar, Janiak, Philip, Suzuki, Teri, Mercola, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658660/
https://www.ncbi.nlm.nih.gov/pubmed/31346210
http://dx.doi.org/10.1038/s41598-019-46948-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658660/
https://www.ncbi.nlm.nih.gov/pubmed/31346210
http://dx.doi.org/10.1038/s41598-019-46948-5

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