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Comparison of Different Liver Test Thresholds for Drug-Induced Liver Injury: Updated RUCAM versus Other Methods

According to the updated Roussel Uclaf Causality Assessment Method (RUCAM), drug-induced liver injury (DILI) is currently defined based on thresholds of alanine aminotransferase (ALT) levels above 5 × the upper limit of normal (ULN) and/or alkaline phosphatase (ALP) levels greater than 2 × the ULN....

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Detalles Bibliográficos
Autores principales:	Yang, Hongyi, Guo, Daihong, Xu, Yuanjie, Zhu, Man, Yao, Chong, Chen, Chao, Jia, Wangping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658872/ https://www.ncbi.nlm.nih.gov/pubmed/31379581 http://dx.doi.org/10.3389/fphar.2019.00816

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