An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment

Incorporation of inverted cytokine receptor (ICR) such as interleukin (IL)-4 vs. IL-7 (4/7) ICR is one strategy to improve the antitumor activities of chimeric antigen receptor (CAR) modified T (CAR-T) cells facing immunosuppressive cytokines. Here we report a novel interleukin (IL)-4 vs. IL-21 ICR...

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Detalles Bibliográficos
Autores principales: Wang, Yi, Jiang, Hua, Luo, Hong, Sun, Yansha, Shi, Bizhi, Sun, Ruixin, Li, Zonghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658891/
https://www.ncbi.nlm.nih.gov/pubmed/31379876
http://dx.doi.org/10.3389/fimmu.2019.01691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658891/
https://www.ncbi.nlm.nih.gov/pubmed/31379876
http://dx.doi.org/10.3389/fimmu.2019.01691

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