Cargando…

An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment

Incorporation of inverted cytokine receptor (ICR) such as interleukin (IL)-4 vs. IL-7 (4/7) ICR is one strategy to improve the antitumor activities of chimeric antigen receptor (CAR) modified T (CAR-T) cells facing immunosuppressive cytokines. Here we report a novel interleukin (IL)-4 vs. IL-21 ICR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yi, Jiang, Hua, Luo, Hong, Sun, Yansha, Shi, Bizhi, Sun, Ruixin, Li, Zonghai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658891/ https://www.ncbi.nlm.nih.gov/pubmed/31379876 http://dx.doi.org/10.3389/fimmu.2019.01691

Ejemplares similares

Target-Dependent Expression of IL12 by synNotch Receptor-Engineered NK92 Cells Increases the Antitumor Activities of CAR-T Cells
por: Luo, Hong, et al.
Publicado: (2019)

Chimeric anti-GPC3 sFv-CD3ε receptor-modified T cells with IL7 co-expression for the treatment of solid tumors
por: Sun, Yansha, et al.
Publicado: (2022)

FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer
por: Liu, Yifan, et al.
Publicado: (2023)

Combined Adjuvant of Poly I:C Improves Antitumor Effects of CAR-T Cells
por: Di, Shengmeng, et al.
Publicado: (2019)

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment
por: Scarfò, Irene, et al.
Publicado: (2017)

Tumor Microenvironment Immunosuppression: A Roadblock to CAR T-Cell Advancement in Solid Tumors
por: Johnson, Abigail, et al.
Publicado: (2022)

CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment
por: Martinez, Marina, et al.
Publicado: (2019)

Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors
por: Ghahri-Saremi, Navid, et al.
Publicado: (2021)

Revolution of CAR Engineering For Next-Generation Immunotherapy In Solid Tumors
por: Yu, Tao, et al.
Publicado: (2022)

Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma
por: DeCordova, Syreeta, et al.
Publicado: (2020)

The immunosuppressive microenvironment and immunotherapy in human glioblastoma
por: Zhang, Xuehua, et al.
Publicado: (2022)

CAR-T Plus Radiotherapy: A Promising Combination for Immunosuppressive Tumors
por: Qin, Vicky Mengfei, et al.
Publicado: (2022)

Cytokines in CAR T Cell–Associated Neurotoxicity
por: Gust, Juliane, et al.
Publicado: (2020)

Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors
por: Li, Fanfan, et al.
Publicado: (2022)

CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells
por: Thomas, Simone, et al.
Publicado: (2023)

Aberrant metabolic processes promote the immunosuppressive microenvironment in multiple myeloma
por: Lv, Junqiang, et al.
Publicado: (2022)

IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response
por: Petrelli, Alessandra, et al.
Publicado: (2011)

Making CAR T Cells a Solid Option for Solid Tumors
por: Schmidts, Andrea, et al.
Publicado: (2018)

Cancer Stem Cells and Immunosuppressive Microenvironment in Glioma
por: Ma, Qianquan, et al.
Publicado: (2018)

Hypoxic Characteristic in the Immunosuppressive Microenvironment of Hepatocellular Carcinoma
por: Mo, Zhuomao, et al.
Publicado: (2021)

Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage
por: Moens, Leen, et al.
Publicado: (2014)

T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma
por: Gong, Fang, et al.
Publicado: (2019)

Befriending the Hostile Tumor Microenvironment in CAR T-Cell Therapy
por: Lindo, Lorenzo, et al.
Publicado: (2021)

Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy
por: Rangel, Roberto, et al.
Publicado: (2022)

Advances in Hypofractionated Irradiation-Induced Immunosuppression of Tumor Microenvironment
por: Wang, Yuxia
Publicado: (2021)

Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies
por: Huang, Boyuan, et al.
Publicado: (2023)

Transcriptome and single-cell analysis reveal the contribution of immunosuppressive microenvironment for promoting glioblastoma progression
por: Ni, Lulu, et al.
Publicado: (2023)

Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors
por: Sloas, Christopher, et al.
Publicado: (2021)

Clinical Investigations of CAR-T Cell Therapy for Solid Tumors
por: Chen, Kun, et al.
Publicado: (2022)

Efficient growth suppression in pancreatic cancer PDX model by fully human anti-mesothelin CAR-T cells
por: Jiang, Hua, et al.
Publicado: (2017)

Overexpression of SMS in the tumor microenvironment is associated with immunosuppression in hepatocellular carcinoma
por: Xiang, Lin, et al.
Publicado: (2022)

Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment
por: Cruz Cruz, Joselyn, et al.
Publicado: (2023)

An integrated overview of the immunosuppression features in the tumor microenvironment of pancreatic cancer
por: Guo, Jinglong, et al.
Publicado: (2023)

CAR T Cell Locomotion in Solid Tumor Microenvironment
por: Nguyen, Duy T., et al.
Publicado: (2022)

Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology
por: Watanabe, Keisuke, et al.
Publicado: (2018)

Engineered Cytokine Signaling to Improve CAR T Cell Effector Function
por: Bell, Matthew, et al.
Publicado: (2021)

Anti-cancer Therapies Employing IL-2 Cytokine Tumor Targeting: Contribution of Innate, Adaptive and Immunosuppressive Cells in the Anti-tumor Efficacy
por: Mortara, Lorenzo, et al.
Publicado: (2018)

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape
por: Rodriguez-Garcia, Alba, et al.
Publicado: (2020)

Reducing Hinge Flexibility of CAR-T Cells Prolongs Survival In Vivo With Low Cytokines Release
por: Zhang, Ang, et al.
Publicado: (2021)

CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies
por: Knochelmann, Hannah M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_02uh3njcout1t51he5h6eqj88e