EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer

BACKGROUND: Growth factors, such as EGF, activate the PI3K/Akt/mTORC1 signalling pathway, which regulates a distinct program of protein synthesis leading to cell growth. This pathway relies on mTORC1 sensing sufficient levels of intracellular amino acids, such as leucine, which are required for mTOR...

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Detalles Bibliográficos
Autores principales: Zhang, Blake K., Moran, Anne M., Bailey, Charles G., Rasko, John E. J., Holst, Jeff, Wang, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659227/
https://www.ncbi.nlm.nih.gov/pubmed/31345230
http://dx.doi.org/10.1186/s12964-019-0400-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659227/
https://www.ncbi.nlm.nih.gov/pubmed/31345230
http://dx.doi.org/10.1186/s12964-019-0400-0

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