Imputation strategies when a continuous outcome is to be dichotomized for responder analysis: a simulation study

BACKGROUND: In many clinical trials continuous outcomes are dichotomized to compare proportions of patients who respond. A common and recommended approach to handling missing data in responder analysis is to impute as non-responders, despite known biases. Multiple imputation is another natural choic...

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Detalles Bibliográficos
Autores principales: Floden, Lysbeth, Bell, Melanie L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659229/
https://www.ncbi.nlm.nih.gov/pubmed/31345166
http://dx.doi.org/10.1186/s12874-019-0793-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659229/
https://www.ncbi.nlm.nih.gov/pubmed/31345166
http://dx.doi.org/10.1186/s12874-019-0793-x

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