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Imputation strategies when a continuous outcome is to be dichotomized for responder analysis: a simulation study
BACKGROUND: In many clinical trials continuous outcomes are dichotomized to compare proportions of patients who respond. A common and recommended approach to handling missing data in responder analysis is to impute as non-responders, despite known biases. Multiple imputation is another natural choic...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659229/ https://www.ncbi.nlm.nih.gov/pubmed/31345166 http://dx.doi.org/10.1186/s12874-019-0793-x |