Global view of the RAF-MEK-ERK module and its immediate downstream effectors

Small molecule inhibitors of BRAF and MEK have proven effective at inhibiting tumor growth in melanoma patients, however this efficacy is limited due to the almost universal development of drug resistance. To provide advanced insight into the signaling responses that occur following kinase inhibitio...

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Detalles Bibliográficos
Autores principales: Santini, Cristina C., Longden, James, Schoof, Erwin M., Simpson, Craig D., Jeschke, Grace R., Creixell, Pau, Kim, Jinho, Wu, Xuewei, Turk, Benjamin E., Rosen, Neal, Poulikakos, Poulikos I., Linding, Rune
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659682/
https://www.ncbi.nlm.nih.gov/pubmed/31350469
http://dx.doi.org/10.1038/s41598-019-47245-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659682/
https://www.ncbi.nlm.nih.gov/pubmed/31350469
http://dx.doi.org/10.1038/s41598-019-47245-x

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