Cargando…
Global view of the RAF-MEK-ERK module and its immediate downstream effectors
Small molecule inhibitors of BRAF and MEK have proven effective at inhibiting tumor growth in melanoma patients, however this efficacy is limited due to the almost universal development of drug resistance. To provide advanced insight into the signaling responses that occur following kinase inhibitio...
Autores principales: | Santini, Cristina C., Longden, James, Schoof, Erwin M., Simpson, Craig D., Jeschke, Grace R., Creixell, Pau, Kim, Jinho, Wu, Xuewei, Turk, Benjamin E., Rosen, Neal, Poulikakos, Poulikos I., Linding, Rune |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659682/ https://www.ncbi.nlm.nih.gov/pubmed/31350469 http://dx.doi.org/10.1038/s41598-019-47245-x |
Ejemplares similares
-
RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF
por: Poulikakos, Poulikos I., et al.
Publicado: (2010) -
Cells, shared memory and breaking the PTM code
por: Creixell, Pau, et al.
Publicado: (2012) -
Unmasking Determinants of Specificity in the Human Kinome
por: Creixell, Pau, et al.
Publicado: (2015) -
Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling
por: Creixell, Pau, et al.
Publicado: (2015) -
“RAF” neighborhood: Protein–protein interaction in the Raf/Mek/Erk pathway
por: Cseh, Botond, et al.
Publicado: (2014)