Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface

Amyloid-β (Aβ) harbors numerous posttranslational modifications (PTMs) that may affect Alzheimer’s disease (AD) pathogenesis. Here we present the 1.1 Å resolution MicroED structure of an Aβ 20–34 fibril with and without the disease-associated PTM, L-isoaspartate, at position 23 (L-isoAsp23). Both wi...

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Detalles Bibliográficos
Autores principales: Warmack, Rebeccah A., Boyer, David R., Zee, Chih-Te, Richards, Logan S., Sawaya, Michael R., Cascio, Duilio, Gonen, Tamir, Eisenberg, David S., Clarke, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659688/
https://www.ncbi.nlm.nih.gov/pubmed/31350392
http://dx.doi.org/10.1038/s41467-019-11183-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659688/
https://www.ncbi.nlm.nih.gov/pubmed/31350392
http://dx.doi.org/10.1038/s41467-019-11183-z

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