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Activity-dependent changes in synaptic protein complex composition are consistent in different detergents despite differential solubility

At the post-synaptic density (PSD), large protein complexes dynamically form and dissociate in response to synaptic activity, comprising the biophysical basis for learning and memory. The use of detergents to isolate the PSD and release its membrane-associated proteins complicates studies of these a...

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Detalles Bibliográficos
Autores principales: Lautz, Jonathan D., Gniffke, Edward P., Brown, Emily A., Immendorf, Karen B., Mendel, Ryan D., Smith, Stephen E. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659712/
https://www.ncbi.nlm.nih.gov/pubmed/31350430
http://dx.doi.org/10.1038/s41598-019-46690-y