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Ammonia induces calpain-dependent cleavage of CRMP-2 during neurite degeneration in primary cultured neurons

Hyperammonemia in the CNS induces irreversible damages to neurons due to ultimate cell loss. Neurite degeneration, a primary event that leads to neuronal cell death, remains less elucidated especially in hyperammonemia circumstances. Here, we found that the administration of ammonia induced neurite...

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Detalles Bibliográficos
Autores principales: Cai, Zhenbin, Zhu, Xiaonan, Zhang, Guowei, Wu, Fengming, Lin, Hongsheng, Tan, Minghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660054/
https://www.ncbi.nlm.nih.gov/pubmed/31278888
http://dx.doi.org/10.18632/aging.102053