Glyco-conjugated bile acids drive the initial metaplastic gland formation from multi-layered glands through crypt-fission in a murine model

Bile acid reflux is known to be associated with the development of Barrett’s esophagus and esophageal adenocarcinoma (EAC), yet the role of specific bile acids and the mechanism behind the metaplastic changes is unclear. Here, we demonstrate that multi-layered glandular structures at the squamo-colu...

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Detalles Bibliográficos
Autores principales: Straub, Danielle, Oude Elferink, Ronald P. J., Jansen, Peter L. M., Bergman, Jacques J. G. H. M., Parikh, Kaushal, Krishnadath, Kausilia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660124/
https://www.ncbi.nlm.nih.gov/pubmed/31348796
http://dx.doi.org/10.1371/journal.pone.0220050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660124/
https://www.ncbi.nlm.nih.gov/pubmed/31348796
http://dx.doi.org/10.1371/journal.pone.0220050

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