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Quantification of Double Stranded DNA Breaks and Telomere Length as Proxies for Corneal Damage and Replicative Stress in Human Keratoconus Corneas
PURPOSE: The pathogenesis of keratoconus (KC) is multifactorial, and associated with oxidative stress and subsequent DNA damage. We investigate differences in DNA damage and replicative stress in patients with KC, and in healthy and diseased controls. METHODS: We obtained 64 corneal buttons from 27...
Autores principales: | Wisse, Robert P. L., Kuiper, Jonas J. W., Radstake, Timothy R. D., Broen, Jasper C. A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660185/ https://www.ncbi.nlm.nih.gov/pubmed/31372311 http://dx.doi.org/10.1167/tvst.8.4.10 |
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