Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. We reported previously that the SFK LynA is uniquely susceptible to rapid ubiquitin-mediated degradation in macrophages, fu...

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Detalles Bibliográficos
Autores principales: Brian, Ben F, Jolicoeur, Adrienne S, Guerrero, Candace R, Nunez, Myra G, Sychev, Zoi E, Hegre, Siv A, Sætrom, Pål, Habib, Nagy, Drake, Justin M, Schwertfeger, Kathryn L, Freedman, Tanya S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660195/
https://www.ncbi.nlm.nih.gov/pubmed/31282857
http://dx.doi.org/10.7554/eLife.46043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660195/
https://www.ncbi.nlm.nih.gov/pubmed/31282857
http://dx.doi.org/10.7554/eLife.46043

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