Lack of B and T cell reactivity towards IDH1(R132H) in blood and tumor tissue from LGG patients

PURPOSE: Mutations in the isocitrate dehydrogenase-1 gene (IDH1) occur at high frequency in grade II–III gliomas (LGGs). IDH1 mutations are somatic, missense and heterozygous affecting codon 132 in the catalytic pocket of the enzyme. In LGG, most mutations (90%) result in an arginine to histidine su...

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Detalles Bibliográficos
Autores principales: Weenink, Bas, van Brakel, Mandy, Wijers, Rebecca, Sillevis Smitt, Peter A. E., French, Pim J., Debets, Reno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Laboratory Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660510/
https://www.ncbi.nlm.nih.gov/pubmed/31240524
http://dx.doi.org/10.1007/s11060-019-03228-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660510/
https://www.ncbi.nlm.nih.gov/pubmed/31240524
http://dx.doi.org/10.1007/s11060-019-03228-6

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