The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein, and LRRK2 mutants are recognized risk factors for Parkinson’s disease (PD). Although the precise mechanisms that control LRRK2 regulation and function are unclear, the importance of the kinase domain is strongly implicated, since 2...

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Detalles Bibliográficos
Autores principales: Schmidt, Sven H., Knape, Matthias J., Boassa, Daniela, Mumdey, Natascha, Kornev, Alexandr P., Ellisman, Mark H., Taylor, Susan S., Herberg, Friedrich W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660771/
https://www.ncbi.nlm.nih.gov/pubmed/31292254
http://dx.doi.org/10.1073/pnas.1900289116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660771/
https://www.ncbi.nlm.nih.gov/pubmed/31292254
http://dx.doi.org/10.1073/pnas.1900289116

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