Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing

Transcription of transposable elements is tightly regulated to prevent genome damage. KRAB domain-containing zinc finger proteins (KRAB-ZFPs) and KRAB-associated protein 1 (KAP1/TRIM28) play a key role in regulating retrotransposons. KRAB-ZFPs recognize specific retrotransposon sequences and recruit...

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Detalles Bibliográficos
Autores principales: Stoll, Guido A., Oda, Shun-ichiro, Chong, Zheng-Shan, Yu, Minmin, McLaughlin, Stephen H., Modis, Yorgo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660772/
https://www.ncbi.nlm.nih.gov/pubmed/31289231
http://dx.doi.org/10.1073/pnas.1901318116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660772/
https://www.ncbi.nlm.nih.gov/pubmed/31289231
http://dx.doi.org/10.1073/pnas.1901318116

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