Cargando…

Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer

PURPOSE: The serine-threonine kinases Aurora A (AURKA) and p21-activated kinase 1 (PAK1) are frequently overexpressed in breast tumors, with overexpression promoting aggressive breast cancer phenotypes and poor clinical outcomes. Besides the well-defined roles of these proteins in control of cell di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Korobeynikov, Vladislav, Borakove, Michelle, Feng, Yayi, Wuest, William M., Koval, Alex B., Nikonova, Anna S., Serebriiskii, Ilya, Chernoff, Jonathan, Borges, Virginia F., Golemis, Erica A., Shagisultanova, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2019
Materias:	Preclinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661032/ https://www.ncbi.nlm.nih.gov/pubmed/31254157 http://dx.doi.org/10.1007/s10549-019-05329-2

Ejemplares similares

Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis
por: Plotnikova, Olga V., et al.
Publicado: (2012)

Aurora A kinase activity influences calcium signaling in kidney cells
por: Plotnikova, Olga V., et al.
Publicado: (2011)

Rapid calcium-dependent activation of Aurora-A kinase
por: Plotnikova, Olga V., et al.
Publicado: (2010)

Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma
por: Özenver, Nadire, et al.
Publicado: (2020)

Aurora A kinase activity influences calcium signaling in kidney cells
por: Plotnikova, Olga V., et al.
Publicado: (2011)

Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease
por: Nikonova, Anna S., et al.
Publicado: (2015)

Triple Targeting of Breast Tumors Driven by Hormonal Receptors and HER2
por: Shagisultanova, Elena, et al.
Publicado: (2022)

A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC) system
por: Sudomoina, Marina, et al.
Publicado: (2004)

Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin
por: Gaponova, Anna V., et al.
Publicado: (2016)

Phospho-(T356)RB1 predicts survival in HPV-negative squamous cell carcinoma of the head and neck
por: Beck, Tim N., et al.
Publicado: (2015)

Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization
por: Ramirez, Ursula D., et al.
Publicado: (2015)

Microscopy-Based Automated Live Cell Screening for Small Molecules That Affect Ciliation
por: Zhang, Peishan, et al.
Publicado: (2019)

Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers
por: Savva, Constantinos, et al.
Publicado: (2019)

Abstract 21 Machine Learning Approach for Automatic Enumeration of Cord Blood Stem Cells by Flow Cytometry
por: Trépanier, Patrick, et al.
Publicado: (2023)

Location-specific and Kinase-Independent GRK5 Function in Heart
por: Wang, Yifan F., et al.
Publicado: (2022)

Concordance of the 21-gene assay between core needle biopsy and resection specimens in early breast cancer patients
por: Qi, Peng, et al.
Publicado: (2021)

Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A Review
por: Gavriilidis, Paschalis, et al.
Publicado: (2015)

Clinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancers
por: Ahmad, Dena A. J., et al.
Publicado: (2016)

Dual compartmental targeting of cell cycle and angiogenic kinases in colorectal cancer models
por: Capasso, Anna, et al.
Publicado: (2018)

Loss of progesterone receptor is associated with distinct tyrosine kinase profiles in breast cancer
por: Tahiri, Andliena, et al.
Publicado: (2020)

HER2/HER3 heterodimers and p21 expression are capable of predicting adjuvant trastuzumab response in HER2+ breast cancer
por: Green, Andrew R., et al.
Publicado: (2014)

Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors
por: Alshaker, Heba, et al.
Publicado: (2018)

A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition
por: Li, Jing, et al.
Publicado: (2021)

With No Lysine Kinase 1 Promotes Metabolic Derangements and RV Dysfunction in Pulmonary Arterial Hypertension
por: Prisco, Sasha Z., et al.
Publicado: (2021)

The molecular mechanism of anticancer action of novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivatives in human gastric cancer cells
por: Pawłowska, Natalia, et al.
Publicado: (2018)

Pleiotropic Effects of Pyruvate Kinase M2 in Right Ventricular Failure and Pulmonary Arterial Hypertension
por: Christou, Helen
Publicado: (2022)

Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer
por: Silva, Grace O., et al.
Publicado: (2015)

Multi-targeted kinase inhibition alleviates mTOR inhibitor resistance in triple-negative breast cancer
por: He, Jichao, et al.
Publicado: (2019)

Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy
por: Al-Subhi, Nouf, et al.
Publicado: (2018)

Chlorogenic acid enhances the effects of 5-fluorouracil in human hepatocellular carcinoma cells through the inhibition of extracellular signal-regulated kinases
por: Yan, Yuan, et al.
Publicado: (2015)

Aurora kinases in ovarian cancer
por: Pérez-Fidalgo, J Alejandro, et al.
Publicado: (2020)

Utilization and impact of 21-gene recurrence score assay for breast cancer in clinical practice across the United States: lessons learned from the 2010 to 2012 National Cancer Data Base analysis
por: Orucevic, Amila, et al.
Publicado: (2016)

Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle
por: Hochegger, Helfrid, et al.
Publicado: (2013)

N-Farnesyloxy-norcantharimide inhibits progression of human leukemic Jurkat T cells through regulation of mitogen-activated protein kinase and interleukin-2 production
por: Chang, Ming-Che, et al.
Publicado: (2015)

Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction
por: Sharp, Thomas E., et al.
Publicado: (2017)

MET-targeting antibody (emibetuzumab) and kinase inhibitor (merestinib) as single agent or in combination in a cancer model bearing MET exon 14 skipping
por: Yan, S. Betty, et al.
Publicado: (2017)

Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2
por: Goyeneche, Alicia A., et al.
Publicado: (2011)

Overcoming Therapeutic Resistance of Triple Positive Breast Cancer with CDK4/6 Inhibition
por: Schedin, Troy B., et al.
Publicado: (2018)

Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer
por: Dotan, E, et al.
Publicado: (2012)

LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models
por: Yan, S. Betty, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7dg5k4qgb0mo1n029ef79g49fs