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In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors
BACKGROUND: Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. In this research rutin, a bioactive flavonoid was explored to determi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661775/ https://www.ncbi.nlm.nih.gov/pubmed/31384818 http://dx.doi.org/10.1186/s13065-019-0585-8 |