Design, synthesis, and biological evaluation of novel N(4)-substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

BACKGROUND: Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities. The inhibition dihydrofolate reductase (DHFR) is considered as one of the most prominent m...

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Detalles Bibliográficos
Autores principales: Hussein, Essam M., Al-Rooqi, Munirah M., Abd El-Galil, Shimaa M., Ahmed, Saleh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661844/
https://www.ncbi.nlm.nih.gov/pubmed/31384838
http://dx.doi.org/10.1186/s13065-019-0603-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661844/
https://www.ncbi.nlm.nih.gov/pubmed/31384838
http://dx.doi.org/10.1186/s13065-019-0603-x

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