Conditional Guide RNAs: Programmable Conditional Regulation of CRISPR/Cas Function in Bacterial and Mammalian Cells via Dynamic RNA Nanotechnology

[Image: see text] A guide RNA (gRNA) directs the function of a CRISPR protein effector to a target gene of choice, providing a versatile programmable platform for engineering diverse modes of synthetic regulation (edit, silence, induce, bind). However, the fact that gRNAs are constitutively active p...

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Detalles Bibliográficos
Autores principales: Hanewich-Hollatz, Mikhail H., Chen, Zhewei, Hochrein, Lisa M., Huang, Jining, Pierce, Niles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661866/
https://www.ncbi.nlm.nih.gov/pubmed/31403072
http://dx.doi.org/10.1021/acscentsci.9b00340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661866/
https://www.ncbi.nlm.nih.gov/pubmed/31403072
http://dx.doi.org/10.1021/acscentsci.9b00340

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