Nimbolide Represses the Proliferation, Migration, and Invasion of Bladder Carcinoma Cells via Chk2-Mediated G2/M Phase Cell Cycle Arrest, Altered Signaling Pathways, and Reduced Transcription Factors-Associated MMP-9 Expression

Nimbolide, an active chemical constituent of Azadirachta indica, reportedly has several physiological effects. Here, we assessed novel anticancer effects of nimbolide against bladder cancer EJ and 5637 cells. Nimbolide treatment inhibited the proliferation of both bladder cancer cell lines with an I...

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Detalles Bibliográficos
Autores principales: Shin, Seung-Shick, Hwang, Byungdoo, Muhammad, Kashif, Gho, Yujeong, Song, Jun-Hui, Kim, Wun-Jae, Kim, Gonhyung, Moon, Sung-Kwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662486/
https://www.ncbi.nlm.nih.gov/pubmed/31391858
http://dx.doi.org/10.1155/2019/3753587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662486/
https://www.ncbi.nlm.nih.gov/pubmed/31391858
http://dx.doi.org/10.1155/2019/3753587

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