Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel

Background: Vinpocetine (VPN) is a synthetic derivative of the Vinca minor alkaloids. The drug is characterized by a short half-life, limited water solubility and high hepatic first-pass effect. The objective was to develop different lipid-based nanocarriers (NCs) loaded into a thermosensitive in si...

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Detalles Bibliográficos
Autores principales: Ahmed, Tarek A, El-Say, Khalid M, Ahmed, Osama AA, Aljaeid, Bader M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662514/
https://www.ncbi.nlm.nih.gov/pubmed/31413562
http://dx.doi.org/10.2147/IJN.S213086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662514/
https://www.ncbi.nlm.nih.gov/pubmed/31413562
http://dx.doi.org/10.2147/IJN.S213086

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